Dr. Philipp-Alexander Neumann is an Associate Professor in the Department of Surgery at the TUM School of Medicine and Health, as well as an Attending Surgeon and Coordinator of the Oncological Colorectal Center at the Department of Surgery, TUM University Hospital, Klinikum rechts der Isar, Technical University of Munich. He currently holds the prestigious Albrecht Struppler Clinician Scientist Fellowship at the Institute for Advanced Study of the Technical University of Munich.
In addition to his clinical career, Dr. Neumann has focused on both basic and clinical research in colorectal surgery, with a special interest in inflammatory bowel diseases (IBD). His postdoctoral fellowship at Emory University in Atlanta, USA, involved participation in numerous projects related to epithelial wound closure and gut inflammation models. Since 2011, his research has concentrated on the role of mediators in intestinal inflammation and anastomotic healing. He has successfully developed preclinical murine models of intestinal anastomotic healing in combination with IBD and colitis models, which have significantly advanced the understanding of intestinal fibrosis, particularly in Crohn’s disease.
Dr. Neumann’s research group investigates various aspects of intestinal wound healing, focusing on anastomotic healing, inflammation, and fibrosis. His work spans multiple patient cohorts, including those with colorectal and esophageal cancer, sepsis, and IBD. He has explored therapeutic approaches such as anti-inflammatory nanoparticles and anastomotic coatings in murine and porcine models to improve postoperative outcomes. In collaboration with Dr. Cira, his group is also studying the role of the microbiome and its perioperative modulation in anastomotic healing within IBD.
Dr. Neumann has been a member of the Academy for Excellence of the German Chairs for Surgery since 2018. This academy recognizes outstanding young surgeons with support for both clinical and scientific excellence.
His work is internationally recognized, with collaborations at institutions such as Imperial College London and the University of Chicago. Dr. Neumann’s research has received funding from prestigious organizations, including the German Research Foundation, the German Cancer Aid, the Federal Ministry of Education and Research, the Else Kröner-Fresenius Foundation, and the Bavarian Research Foundation.
Dr. Neumann is the author of 59 scientific papers published in peer-reviewed journals, with a Scopus h-index of 20 and over 2,000 citations. He serves on the Editorial Board Member of Scientific Reports.
His primary clinical and research interests include colorectal and IBD surgery, minimally invasive and robotic surgery, and the pathophysiology of anastomotic leakage, intestinal inflammation and fibrosis.
Selected publications from PubMed
Feasibility and preliminary results of modeling a clinically meaningful anastomotic leak in pigs.
Hyoju SK, Cira K, McKinley I, Faazal R, Mailhiot D, Ostdiek A, Neumann PA, Alverdy JC
Int J Surg. 2026 Feb 18 doi: 10.1097/JS9.0000000000004959.
Machine Learning for Anastomotic Leak Prediction in Colorectal Surgery-Between Validation and Clinical Implementation.
Cira K, Neumann PA
JAMA Netw Open. 2025 Oct 1;8(10):e2538274 doi: 10.1001/jamanetworkopen.2025.38274.
Perioperative Collagen IV-Targeted Ac2-26 Nanoparticles Enhance Anastomotic Healing in Acute Crohn's Disease-Like Colitis: A Preclinical Study on Systemic, Oral, and Rectal Delivery Routes.
Cira K, Vieregge V, Pollak S, Lee JH, Reischl S, Walter RL, Clees Z, Kasajima A, Metzler T, Friess H, Kamaly N, Neumann PA
Ann Surg. 2025 Sep 5 doi: 10.1097/SLA.0000000000006929.
Role of the serosa in intestinal anastomotic healing: insights from in-depth histological analysis of human and murine anastomoses.
Weber MC, Clees Z, Buck A, Fischer A, Steffani M, Wilhelm D, Martignoni M, Friess H, Rinkevich Y, Neumann PA
BJS Open. 2024 Sep 3;8(5) doi: 10.1093/bjsopen/zrae108.
A nationwide population-based study on the clinical and economic burden of anastomotic leakage in colorectal surgery.
Weber MC, Berlet M, Stoess C, Reischl S, Wilhelm D, Friess H, Neumann PA
Langenbecks Arch Surg. 2023 Jan 23;408(1):55 doi: 10.1007/s00423-023-02809-4.
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