Stavros A. Antoniou was born in Athens, Greece. He received his undergraduate degree in Thessaloniki, Greece and postgraduate clinical and research training in Germany and in Greece. He holds a PhD in minimally invasive surgery, a Master Degree in Public Health and Health Business Administration and he is a Fellow of the European Board of Surgery. His scholarly work is focused on synthesis of evidence (meta-analysis, meta-regression, trial sequential analysis, network meta-analysis) and he has performed research on the quality of surgical trials. He has served as head or member of several guidelines development groups and is associate editor and member of editorial board in numerous peer-reviewed journals. He is chair of the European Association for Endoscopic Surgery Consensus & Guideline Subcommittee and member of the United European Gastroenterology Quality of Care Task Force. He is scientific collaborator at the European University Cyprus and practises General & Colorectal Surgery at the Mediterranean Hospital of Cyprus in Limassol, Cyprus.
Selected publications from PubMed
Systematic review and meta-analysis on key controversies in the management of diverticular disease: a multi-society collaboration.
Huo B, Dourado J, Khaldi MA, Ntaga I, Broderick J, Shehata D, Calabrese E, Lingam G, de Sadeleer A, Barbera E, Reinke C, Carrano F, Breukink S, Kaiser A, Marafini I, Biffl W, Catena F, Frizelle F, Doulias T, Tursi A, Kimble J, Buchenholz N, Walls S, Yao X, Guyatt G, Yiasemidou M, Heuvelings D, Garfinkle R, Abou-Khalil M, Slater BJ, Antoniou SA, Bouvy N, Sylla P, Francis N, Boutros M
Surg Endosc. 2026 Sep 1 doi: 10.1007/s00464-026-13297-0.
European Association of Endoscopic Surgery (EAES) Clinical Practice Guidelines Committee: standard operating procedure.
Huo B, Koutsiouroumpa O, Carrano F, Mavridis D, Tzanis AA, Perivoliotis K, Dore S, Bigaki M, Antoniou SA
Surg Endosc. 2026 Aug 31 doi: 10.1007/s00464-026-13313-3.
Correction: A systematic review, meta-analysis and GRADE assessment of the evidence on complete mesocolic excision for right-sided colon cancer with SAGES and ESCP participation.
Tzanis AA, Carrano FM, Perivoliotis K, Kumar SS, Christogiannis C, Mavridis D, Huo B, Bouvy N, Christou N, Dore S, Dulskas A, Kontovounisios C, Lubbers T, Palazzo F, Quirke P, Repana D, Terlizzo M, Slater BJ, Florez ID, Ortenzi M, Arulampalam T, Antoniou SA
Surg Endosc. 2026 Sep;40(9):8225-8226 doi: 10.1007/s00464-026-13166-w.
Development of a robotic training curriculum for visceral and gastrointestinal surgical trainees: an international Delphi study.
Fadel MG, Walshaw J, Yiasemidou M, Boal M, Pecchini F, Elhadi M, Massey LH, Carrano FM, Fehervari M, Walsh CM, Boshier PR, Eckhoff J, Buckle P, ERSC Study Group, Gisbertz SS, Bouvy N, Arezzo A, Perretta S, Nickel F, Khan J, Hanna GB, Seeliger B, Antoniou SA, Fuchs HF, Francis NK, Kontovounisios C
Surg Endosc. 2026 Aug;40(8):6913-6927 doi: 10.1007/s00464-026-12781-x.
Development of a robotic training curriculum for visceral and gastrointestinal surgical trainees: an international Delphi study.
Fadel MG, Walshaw J, Yiasemidou M, Boal M, Pecchini F, Elhadi M, Massey LH, Carrano FM, Fehervari M, Walsh CM, Boshier PR, Eckhoff J, Buckle P, European Robotic Surgery Consensus (ERSC) Study Group, Gisbertz SS, Bouvy N, Arezzo A, Perretta S, Nickel F, Khan J, Hanna GB, Seeliger B, Antoniou SA, Fuchs HF, Francis NK, Kontovounisios C
Br J Surg. 2026 Jun 4;113(6) doi: 10.1093/bjs/znag054.
The European Association for Endoscopic Surgery (EAES) Guidelines Committee presents its 2024 recommendations on the surgical management of complicated diverticulitis and complete mesocolic excision (CME) for right-sided colon cancer. Guideline development involves a rigorous process, including topic selection based on member survey, protocol development, and stakeholder engagement. A multidisciplinary team, adhering to GRADE methodology, conducts systematic reviews and meta-analyses. For complicated diverticulitis, a network meta-analysis informed recommendations favoring primary anastomosis over Hartmann's procedure and lavage in terms of stoma-free survival, with similar mortality rates. However, evidence certainty was low to moderate. Patient preferences and cost-effectiveness analysis supported primary anastomosis. Conditional recommendations were issued based on patient factors and surgeon expertise. For CME, the analysis of RCTs and cohort studies demonstrated improved overall survival compared to standard resection, with no significant differences in other outcomes. Despite low to moderate evidence certainty, a conditional recommendation for CME was issued where expertise is available. Both guidelines highlight the importance of balancing benefits and harms, considering patient preferences, and addressing implementation challenges. The full guidelines will be available in September 2024, with detailed discussions in Surgical Endoscopy.
Published
Sep 2024
Bowel preparation practices vary, and a survey of EAES members prioritized this topic to be addressed by a clinical practice guideline. This prompted the EAES Guidelines Subcommittee to develop evidence-informed clinical practice recommendations on the use of bowel preparation before minimally invasive colorectal surgery, through evidence synthesis and a structured evidence-to-decision framework by an interdisciplinary panel of surgeons, anesthetists, infectious disease specialists, and patient partners. The panel suggests either oral antibiotics alone prior to minimally invasive right colon resection, or mechanical bowel preparation (MBP) plus oral antibiotics; MBP plus oral antibiotics prior to minimally invasive left colon and sigmoid resection, and prior to minimally invasive right colon resection when there is an intention to perform intracorporeal anastomosis; MBP plus oral antibiotics plus enema prior to minimally invasive rectal surgery; and recommends MBP plus oral antibiotics prior to minimally invasive colorectal surgery, when there is an intention to localize the lesion intraoperatively (strong recommendation).
Published
Oct 2023
Clinical practice guidelines (CPGs) summarize research and empirical evidence to inform the development of recommendations for clinical or policy decision making. The methodology of guideline development has evolved over the past decades, with the contribution of major organizations, such as the Guidelines International Network, the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) Working Group, and the Scottish Intercollegiate Guidelines Network (SIGN). Further efforts have focused on the improvement of CPG reporting. The Appraisal of Guidelines, Research and Evaluation (AGREE) Collaboration developed an instrument to be used as a guide on how to design, report and assess CPGs. The AGREE II checklist and the AGREE II instrument have been adopted by several guideline-development bodies, including WHO, as reporting and appraisal tools, respectively. CPGs on surgical interventions are somewhat unique, compared to non-interventional guidelines. For instance, surgical interventions are often operator-dependent, and they usually require specific skills and expertise. Defining the required resources and expertise to implement the recommendations might be considered important by target users and other stakeholders. Furthermore, guidelines on surgical intervention may need to provide sufficient details of the procedure to enable the extrapolation of evidence to clinical practice (e.g. the method of access and the type of stent to be used in endovascular aortic aneurysm repair), as opposed to non-interventional and pharmacological guidelines, where the management options are usually straightforward (e.g. using low molecular heparin over unfractionated heparin for prevention of deep vein thrombosis). These considerations, in addition to advances in guideline development methodology in recent years, prompted a group of guideline developers in the field of surgery to design an extension of the original AGREE II instrument, which would apply to guidelines on surgical interventions. In this talk we describe the development of the AGREE-S reporting checklist, an AGREE II extension for surgical interventions.
Published
Oct 2021
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