Cardiothoracic Surgery
Head and Chief Specialist, Department of Cardiothoracic Surgery, University of KwaZulu Natal, Inkosi Albert Luthuli Central and King DinuZulu Hospitals, South Africa
Dr. Rajhmun Madansein is the Head and Chief Specialist in the Department of Cardiothoracic Surgery, the University of KwaZulu Natal, Inkosi Albert Luthuli Central and King DinuZulu Hospitals, South Africa. He was previously an associate in the Therapeutic Immunology Division, at Karolinska Institute, Stockholm. He heads a Department that does probably the most interventions for Thoracic TB in South Africa. King DinuZulu Hospital is one of the largest TB hospitals in SA. One of his main research, clinical and teaching interests is surgery for TB including drug-resistant TB and understanding the pathophysiology of TB in the human lung. He also has a long-standing collaboration with the Africa Health Research Institute, one of the largest TB research laboratories on the African continent. He has published extensively on this topic in peer-reviewed journals.
Selected publications from PubMed
NETosis associates with human TB lung tissue destruction and disease pathogenesis.
Fisher KL, Mpotje T, Nargan K, Moodley D, Rajkumar-Bhugeloo K, Baiyegunhi OO, Naidoo T, Madansein R, Sathekge M, Leslie A, Tomlinson G, Pollara G, Noursadeghi M, Steyn AJC, Ndung'u T, Marakalala MJ
EMBO Mol Med. 2026 Jul;18(7):2547-2572 doi: 10.1038/s44321-026-00435-3.
B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles.
Krause R, Ogongo P, Tezera L, Ahmed M, Mbano I, Chambers M, Ngoepe A, Magnoumba M, Muema D, Karim F, Khan K, Lumamba K, Nargan K, Madansein R, Steyn A, Shalek AK, Elkington P, Leslie A
Commun Biol. 2024 May 16;7(1):584 doi: 10.1038/s42003-024-06282-7.
Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control.
Gideon HP, Hughes TK, Tzouanas CN, Wadsworth MH 2nd, Tu AA, Gierahn TM, Peters JM, Hopkins FF, Wei JR, Kummerlowe C, Grant NL, Nargan K, Phuah JY, Borish HJ, Maiello P, White AG, Winchell CG, Nyquist SK, Ganchua SKC, Myers A, Patel KV, Ameel CL, Cochran CT, Ibrahim S, Tomko JA, Frye LJ, Rosenberg JM, Shih A, Chao M, Klein E, Scanga CA, Ordovas-Montanes J, Berger B, Mattila JT, Madansein R, Love JC, Lin PL, Leslie A, Behar SM, Bryson B, Flynn JL, Fortune SM, Shalek AK
Immunity. 2022 May 10;55(5):827-846.e10 doi: 10.1016/j.immuni.2022.04.004.
On-X mitral valve leaflet embolization presenting as acute pulmonary oedema.
Sidali L, Ndibi N, Moopanar M, Madansein R
Egypt Heart J. 2022 May 4;74(1):36 doi: 10.1186/s43044-022-00270-0.
HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells.
Reuschl AK, Mesner D, Shivkumar M, Whelan MVX, Pallett LJ, Guerra-Assunção JA, Madansein R, Dullabh KJ, Sigal A, Thornhill JP, Herrera C, Fidler S, Noursadeghi M, Maini MK, Jolly C
Cell Rep. 2022 Apr 12;39(2):110650 doi: 10.1016/j.celrep.2022.110650.
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