I am a physician scientist working in the field of molecular pathology, tumor immunology, hereditary cancer, and cancer evolution. My research dedicated to the immune evolution of mismatch repair-deficient cancers has led to a first-in-human clinical trial examining the feasibility of cancer immune prevention in Lynch syndrome. My clinical expertise covers molecular tumor diagnostics with a particular emphasis on microsatellite instability and mismatch repair deficiency (MSI/MMRd). My current activities aim at the integration of artificial intelligence/machine learning, mathematical modelling, and immune biology for tailored cancer prevention, interception, and therapy,.
Selected publications from PubMed
Quantifying cell divisions along evolutionary lineages in cancer.
Blohmer M, Cheek DM, Hung WT, Kessler M, Chatzidimitriou F, Wang J, Hung W, Lee IH, Gorelick AN, Wassenaar EC, Yang CY, Yeh YC, Ho HL, Speiser D, Karsten MM, Lanuti M, Pai SI, Kranenburg O, Lennerz JK, Chou TY, Kloor M, Naxerova K
Nat Genet. 2025 Mar;57(3):706-717 doi: 10.1038/s41588-025-02078-5.
Distinct Mutational Profile of Lynch Syndrome Colorectal Cancers Diagnosed under Regular Colonoscopy Surveillance.
Ahadova A, Pfuderer PL, Ahtiainen M, Ballhausen A, Bohaumilitzky L, Kösegi S, Müller N, Tang YL, Kosmalla K, Witt J, Endris V, Stenzinger A, von Knebel Doeberitz M, Bläker H, Renkonen-Sinisalo L, Lepistö A, Böhm J, Mecklin JP, Seppälä TT, Kloor M
J Clin Med. 2021 Jun 1;10(11) doi: 10.3390/jcm10112458.
European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender.
Seppälä TT, Latchford A, Negoi I, Sampaio Soares A, Jimenez-Rodriguez R, Sánchez-Guillén L, Evans DG, Ryan N, Crosbie EJ, Dominguez-Valentin M, Burn J, Kloor M, Knebel Doeberitz MV, Duijnhoven FJBV, Quirke P, Sampson JR, Møller P, Möslein G, European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)
Br J Surg. 2021 May 27;108(5):484-498 doi: 10.1002/bjs.11902.
Differential Effects of Trp53 Alterations in Murine Colorectal Cancer.
Betzler AM, Nanduri LK, Hissa B, Blickensdörfer L, Muders MH, Roy J, Jesinghaus M, Steiger K, Weichert W, Kloor M, Klink B, Schroeder M, Mazzone M, Weitz J, Reissfelder C, Rahbari NN, Schölch S
Cancers (Basel). 2021 Feb 15;13(4) doi: 10.3390/cancers13040808.
The "unnatural" history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance.
Ahadova A, Seppälä TT, Engel C, Gallon R, Burn J, Holinski-Feder E, Steinke-Lange V, Möslein G, Nielsen M, Ten Broeke SW, Laghi L, Dominguez-Valentin M, Capella G, Macrae F, Scott R, Hüneburg R, Nattermann J, Hoffmeister M, Brenner H, Bläker H, von Knebel Doeberitz M, Sampson JR, Vasen H, Mecklin JP, Møller P, Kloor M
Int J Cancer. 2021 Feb 15;148(4):800-811 doi: 10.1002/ijc.33224.
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