

Colorectal Surgery
MBBChir, PhD, FRCS, FACCRS (hon)., Professor of Surgery, Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Chief Academic Officer and Clinical Director of Research, Cleveland Clinic London, UK
Charles Knowles is Chief Academic Officer and Clinical Director of Research and Innovation at the Cleveland Clinic London, Professor of Surgery at Queen Mary University of London and an honorary Consultant Colorectal surgeon at Barts Health NHS Trust and St Marks Hospitals. He is also the Chief Medical Officer of Amber Therapeutics Ltd.
Prof. Knowles qualified from the University of Cambridge and undertook general surgical training and a PhD in London. His main research interests cover the development and evaluation of new technologies for the diagnosis and treatment of chronic functional and neuromuscular disorders of the bowel and pelvic floor (with a focus on neuromodulation and cell therapies). Clinically, he is a key international opinion leader on chronic constipation, incontinence, pelvic organ prolapse and GI neuromuscular diseases.
Professor Knowles holds honorary chairs at University College London and the University of Antwerp. He has authored over 300 peer-reviewed publications (H-index: 70) as well as contributing to major international colorectal and general surgical texts, national guidance and health policy documents. He was awarded an honorary fellowship of the American Society of Colon and Rectal Surgeons in 2021. Aside from his day job(s), Professor Knowles is a semi-professional musician, songwriter and author.
Selected publications from PubMed
Assessment of Perinatal Pelvic Floor Dysfunction Symptoms and Risk Factors: Measurement Properties of the International Consultation on Incontinence-Perinatal Pelvic Health Self-Assessment Questionnaire (ICIQ-PPHSAQ).
Uren A, Fee A, Abrams P, Avery K, Sucha E, Barrowman N, Bale N, Draycott T, Elhodaiby M, Emkes J, Hashim H, Knowles C, Lough K, Madhu C, McCarthy K, Norrie J, Pinkstone J, Soodeen S, Ward K, Cotterill N
BJOG. 2026 Sep;133(10):1876-1884 doi: 10.1111/1471-0528.70236.
2025 Canadian Surgery Forum: Sept. 17-20, 2025.
Russell B, Stewart D, Devon K, Mallette K, Ehlebracht A, Mimeault R, Savoy T, Garber G, Yan Q, MacIntyre A, Liu R, Mostafapour M, Balaa F, Klapman S, Yacob M, Guo M, Rebello L, Karimuddin A, Sutherland J, Mamalchi SA, Choi D, Ivankovic V, Cornacchia M, Shorr R, Glen P, Matar M, Balaa F, Ammeter D, Johnson G, Askin N, Helewa R, Hyun E, Hochman D, Anant S, Wadhwa A, Lee J, Auer R, Fallavollita P, Shanahan J, Evans B, Follett A, MacDonald M, McGrath A, Hartwig K, Farrell T, Courage E, LeBlanc D, Borgaonkar M, Pace D, Trinh F, Fujita K, Ahmed H, Kung J, Jogiat U, Jatana S, Karmali S, Switzer N, Mocanu V, Lalande A, Eppler E, Gadhari N, Zhao J, MacNeill AJ, Hilzenrat R, Livergant R, Binda C, Adams J, Joos E, Joharifard S, Chin E, Haji F, Pook M, Najafi T, Wong S, Boutros M, Fried G, Lee L, Feldman LS, Fiore J Jr, Nair AG, Giannakeas V, Lim D, Li C, Litvinchuk S, Saleh A, Bondzi-Simpson A, Ribeiro T, Covelli A, Lofters A, Sutradhar R, Snyder RA, Clarke CN, Coburn N, Hallet J, Macdonald L, Montgomery-Song A, Li T, Hannedige D, Neumann K, Knapp G, Drohan A, Spence R, Alibhai K, McFadgen H, Brar S, Ott M, Hamstra S, Louridas M, McLennan S, Forrester E, Kung JY, Switzer N, Habash A, Lee J, Park Y, Al-Zoubi F, Gilbert S, Fallavollita P, Zhao J, Dono A, Jung C, Salvemini J, Sheridan B, Zhao C, Valaulikar G, Ng T, Griffiths C, Patel Y, Nocula A, Haider E, Agzarian J, Hanna W, Brar K, Xiao K, Wong R, Elimova E, Jang R, Ma L, Darling G, Wakeam E, Yan M, Barron C, Mesci A, Yeung J, Lukovic J, Rioux A, Provencher S, Simard S, Bussières J, Couture É, Grégoire J, Conti M, Laliberté AS, French D, Abdul SA, Anstee C, Jones D, Taljaard M, Seely A, Philpott H, Murphy R, McCausland C, Gao Y, Gingrich M, Anstee C, Seely A, Wallace A, Sticca G, Zamani E, Selb J, Gagnon-Konamna M, Sebajang H, Schwenter F, De Broux E, Chartrand G, Wassef R, Ratelle R, Loungnarath R, Ember K, Dagbert F, Leblond F, Richard C, Brennan K, Ricci A, Knight K, McKechnie T, Bennett S, Patel S, Wu S, Maalouf CM, Lougnarath R, Dagbert F, Ratelle R, Gagnon-Konamna M, Schwenter F, Sebajang H, Wassef R, DeBroux É, Richard C, Muncner S, Dosanjh J, Dykstra M, Snelgrove R, Wang H, Ahn HS, Williams A, Kelly K, Moloo H, Sticca G, Abou-Khalil M, Soucisse M, Tremblay JF, Gervais MK, Sideris L, Hu R, McIsaac D, Musselman R, van Walraven C, Garfinkle R, Demian M, Sabboobeh S, Bhatnagar S, Savard J, Drolet S, Liberman S, Brown C, Park J, Moon J, Loiselle C, Wexner S, Bordeianou L, Ghitulescu G, Faria J, Morin N, Vasilevsky CA, Boutros M, Wang C, MacLean A, Buie D, Gimon T, Pereira A, Kuforiji O, Dalgarno N, Pereira J, Farooq A, Patel S, Monton O, DiVenti C, Sabboobeh S, Emile SH, Wexner SD, Fiore JF Jr, Bordeianou LG, Cornish J, Christensen P, Emmertsen KJ, Oliveira L, Marinello F, Dulskas A, Wilson K, Knowles CH, Burch J, Boutros M, Bondzi-Simpson A, Sutradhar R, Zhu A, Lofters A, Covelli A, Snyder RA, Clarke CN, Coburn N, Hallet J, Muncner S, Dosanjh J, Lin A, Ng C, Dykstra M, Snelgrove R, Jaremko J, Wang H, Baig Z, Karimuddin A, Phang T, Ghuman A, Raval M, Kennedy E, Brown C, Ahn HS, Hu R, Chahrour M, Williams L, Raiche I, Boushey R, Friedlich M, Moloo H, Musselman R, Aggarwal I, Taqi K, Ichhpuniani S, Stockley C, Assadzadeh G, Dixon E, Mack L, Bouchard-Fortier A, Rouhi A, Verhoeff K, Parente A, Sutcliffe R, Downey J, Raheel R, Tsang R, Lupichuk S, Quan ML, Laws A, Ng D, Babichev Y, Nash J, Gladdy R, Varvaris L, Shlien A, Campbell K, Swallow C, Pillar M, Flor L, Trasolini R, Hamilton T, Ribeiro T, Bondzi-Simpson A, Chan W, Mahar A, Jerath A, Coburn N, Hallet J, Lafortune R, Bénard F, Mercier F, Colivas J, Noyon B, Gervais C, Osman Y, Sticca G, Schaulin M, Huang TY, Elkouri S, Caron M, Bénard F, Dumas LM, Abdelli R, Soleimani Y, Kaviani A, Boulva K, Younan R, Hassan S, Khoury ME, Patocskai E, Alshammari R, Youn S, Flor L, Smrke A, Hamilton T, Zhu A, Bondzi-Simpson A, Mahar A, Hsu A, James P, Ante Z, Ip KI, Kosyachkova E, Hallet J, Coburn N, Rao A, Kalyvas M, Wilson B, Patel S, Farooq A, Bennett S, Samarasinghe N, Cusano AD, Kessler V, Townsend J, Joarder I, Stewart M, Oldani G, Segedi M, Chartier-Plante S, Bleszynski M, Pang E, Kim PTW, Ivankovic V, Mallette K, Carrier FM, Wherrett C, Vanterpool Z, Brousseau K, Monette L, Workneh A, Ruel M, Sabri E, Maddison H, Tokessy M, Wong PBY, McGinn R, Vandenbroucke-Menu F, Massicotte L, Chassé M, Collin Y, Perrault MA, Hamel-Perreault É, Park J, Lim S, Maltais V, Leung P, Gilbert RWD, Segedi M, Abou-Khalil J, Bertens KA, Balaa FK, Ramsay T, Tinmouth A, Fergusson D, Martel G, Czarnecka Z, Verhoeff K, Carr ALJ, Lam A, Senior P, Lucciantonio R, Kin T, Pepper AR, Bigam DL, Dajani K, Anderson B, Shapiro AMJ, Khalid MU, Aldekhayel M, Kwon M, Cino S, Kim DH, Gilbert R, Bleszynski M, Oldani G, Segedi M, Chartier-Plante S, Kim PTW, Liang H, AlQatan A, Ball CG, Ahmed S, Macmillan J, Matic J, Moser M, Marritt K, Mainprize M, Svendrovski A, Smith D, Simmons C, Henao-Florez O, Hennessey RL, Smith L, Melland-Smith M, Yilbas A, Mainprize M, Svendrovski A, Paasch C, Katz J, Karmustaji A, Alahmed S, Yang Y, Chiu CJ, Meneghetti A, Hennessey RL, Abbas U, Srikrishnaraj D, Safar A, Hawel J, Schlachta C, Elnahas A, Rajkumar G, Chiu CJ, Chartier-Plante S, Buczkowski A, Meneghetti A, Hennessey RL, El-Kefraoui C, Walker M, Yang Y, Chiu CJ, Meneghetti A, Hennessey RL, Connell M, He W, Prior H, Vergis A, Hardy K, Mackenzie D, Hopman W, Zevin B, Robertson D, Szasz P, Osman H, Gill R, Karmali S, Marcil G, Elkassem S, Debru E, Solomon J, Switzer N, Gill R, Hossain I, Okrainec A, Jackson T, Scott L, Warwick K, Chen K, Whitehead L, Fecso A, Park LJ, Polley H, Poole M, Brar K, McKechnie T, Nenshi R, Borges FK, Ofori S, Marcucci M, Conen D, Eskicioglu C, Hong D, Devereaux PJ, Sagorin Z, Dominguez G, Sampath S, Brar K, Lee YR, Dekirmendjian A, Deng J, Ma O, Okrainec A, Adekoya P, Fabien L, Barlow K, Ramji K, Anvari M, Khamar J, Kazi T, Khan M, Acharya S, Lee Y, Huo B, Ramji K, Boudreau V, Doumouras A, Hong D, Keshavjee S, McKechnie T, Shi V, Kuszaj O, Rattansi S, Brennan K, Patel S, Forbes S, Doumouras A, Parpia S, Bhandari M, Eskicioglu C, Momic J, Allen L, Hilsden R, Rashid S, Brackstone M, Moffat B, Leslie K, Vogt K, DiMatteo B, Allen L, Iansavitchene A, Vogt K, Ehlebracht A, Glen P, Cornacchia M, Balmes P, Kudryk A, Tam W, Rosenkrantz L, Moffat B, Lund M, Rashid S, Allen L, Hilsden R, Parry N, Gray D, Leslie K, Leeper R, Vogt K, Lee A, Narayanan D, Staudenmayer K, Hameed M, Lee A, Chan M, Narayanan D, Hameed M
Can J Surg. 2025 Nov-Dec;68(6suppl2):S27-S57 doi: 10.1503/cjs.019325.
Results of the international audit for faecal incontinence on behalf of the European Society of Coloproctology (ESCP) collaborating group.
Dulskas A, Cerkauskaite D, El-Hussuna A, Gallo G, Dardanov D, Svagzdys S, Singh B, Pinkney T, Pellino G, Glasbey J, van Ramshorst G, Chaudhri S, Frasson M, Pata F, Morton D, Knowles CH, European Society of Coloproctology (ESCP) 2022 Collaborating Group
Colorectal Dis. 2025 Oct;27(10):e70245 doi: 10.1111/codi.70245.
Pathway Of Low Anterior Resection syndrome (LARS) relief after Surgery (POLARiS): protocol for an international, open-label, multi-arm, phase 3 randomised superiority trial within a cohort, with economic evaluation, process evaluation and qualitative sub-study, to explore the natural history of LARS and compare transanal irrigation and sacral neuromodulation to optimised conservative management for people with major LARS following a high or low anterior resection for colorectal cancer.
Croft J, Farrow E, Coxon-Meggy AH, Gordon K, Corrigan N, Mather H, Stocken DD, Dale M, Chong HY, White J, Knight L, Meggy A, Lloydwin C, Tan B, Douglas A, Powell R, Hepburn J, Jayne D, Torkington J, Warwick A, Ng KS, Wilson K, Knowles CH, Quyn A, Cornish J
BMJ Open. 2025 Feb 3;15(2):e092612 doi: 10.1136/bmjopen-2024-092612.
Local Myoelectric Sensing During Human Colonic Tissue Perfusion.
Ben-David M, Makwana R, Yered T, Sanger GJ, Knowles CH, Wasserberg N, Shor E
Diagnostics (Basel). 2024 Dec 20;14(24) doi: 10.3390/diagnostics14242870.
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