with Dr. Sara Nogueira
In this lecture we will go through 5 important things we should know about molecular diagnosis or diagnostics in colorectal cancer.
Clinical Background
First, we will talk about the concept of molecular diagnostics.
Second, we will remember the 3 main genetic pathways behind colorectal cancer development, the different mutations involved in the evolution of a normal cell to a cancer cell and the molecular aspects of hereditary and non-hereditary CRC.
Third, we will show the known molecular differences between right-sided and left-sided cancer and their implications in the different phenotypes and prognosis.
Fourth, we will talk about the different diagnostic markers, their clinical implications and how to test for them.
And Fifth, and finally we will discuss the therapeutic and prognostic implications of these molecular markers and an algorithm for testing.
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